BLTP3A dysfunction unleashes lysosomal stress-induced antitumor immunity through STING
Elaheh Sadat Hosseini, Steven Wang, Mona Arabzadeh, Kristen E. Warrington, Maria T. Søgaard, Amartya Singh, Wenjin Chen, Lomaani Ranasinghe, Rinkee Kumari, Christopher Alcott, Adam Robinson, Shreya Yadav, Wenwei Hu, Jian Cao, Eugenia Girda, , Kyle Kristopher Payne
This study shows that BLTP3A dysfunction leads to lysosomal stress, which activates STING and promotes antitumor immunity by sustaining IFN-λ production in ovarian cancer.
bioRxiv · Sep 28, 2026 · PreprintCancer Biology