Christian S. Hinrichs

This study shows that BLTP3A dysfunction leads to lysosomal stress, which activates STING and promotes antitumor immunity by sustaining IFN-λ production in ovarian cancer.

This study identifies OSTM1 as a tumor suppressor in B-cell malignancies by showing it activates the cAMP/PKA/CREB pathway through ubiquitin E3 ligase activity.

This study shows that mitochondrial DNA mutations in NSCLC cause respiration defects, leading to glucose dependency, reduced serine synthesis, and increased cancer survival.

This paper shows that immune checkpoint blockade (ICB) can delay cancer onset and improve survival in mice with mutator syndromes, but only if administered prophylactically before tumors develop.