SRRM1 coordinates an alternative splicing program that promotes expression of oncogenic protein isoforms.
Kamal Othman, Lauren Viola, Hira Fatima, Jessica Lapierre, Graham Dickson and Hugh MacLeod, Craig D. Simpson, Christopher Chu, Russell Beltran, Yangjing Zhang, Stéphane Angers, Olivier Saulnier, C. Jane McGlade
This study identifies SRRM1 as a splicing regulator that promotes oncogenic NUMB isoforms and other cancer-related splicing events, leading to increased tumorigenic properties in multiple cancer cell lines.
bioRxiv · Aug 20, 2025 · PreprintCancer Biology