Craig D. Simpson

Targeting CBL ubiquitin ligase activation to downregulate tyrosine kinase signalling

This study demonstrates that activating CBL ubiquitin ligase via engineered mutants or small molecules can downregulate tyrosine kinase signaling by enhancing substrate ubiquitination and reducing downstream signaling.

SRRM1 coordinates an alternative splicing program that promotes expression of oncogenic protein isoforms.

This study identifies SRRM1 as a splicing regulator that promotes oncogenic NUMB isoforms and other cancer-related splicing events, leading to increased tumorigenic properties in multiple cancer cell lines.

SLAP2 adaptor binding disrupts c-CBL autoinhibition to activate ubiquitin ligase function.

This study identifies how SLAP2 binding to CBL disrupts its autoinhibition, revealing a mechanism for activating CBL's ubiquitin ligase function.

Probability-based detection of phosphoproteomic uncertainty reveals rare signaling events driven by oncogenic kinase gene fusion

The paper introduces a Bayesian method to estimate protein concentrations and phosphorylation site occupancy ratios from mass spectrometry data, applied to study PRKAR1A-RET gene fusion effects.