Author

Yangjing Zhang

University of TorontoORCID 0000-0003-3762-0767Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

C. Jane McGladeiD· 3 shared Christopher Chu· 1 shared Craig D. SimpsoniD· 1 shared Graham Dickson and Hugh MacLeodiD· 1 shared Hira Fatima· 1 shared Jessica Lapierre· 1 shared Kamal OthmaniD· 1 shared Lauren ViolaiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

C. Jane McGladeORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 20, 2025

SRRM1 coordinates an alternative splicing program that promotes expression of oncogenic protein isoforms.

Kamal Othman, Lauren Viola, Hira Fatima…·C. Jane McGlade

This study identifies SRRM1 as a splicing regulator that promotes oncogenic NUMB isoforms and other cancer-related splicing events, leading to increased tumorigenic properties in multiple cancer cell lines.

DOI 10.1101/2025.08.20.671097

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintAug 11, 2025

Alternative splicing of NUMB correlates with tumor immune evasion and metabolic adaptation.

Yangjing Zhang, C. Jane McGlade

The paper shows that high NUMB exon 9 inclusion in tumors is linked to immune evasion and metabolic changes that support tumor growth.

1 citation

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintSep 26, 2023

Pan tissue analysis of human NUMB alternative splicing.

Yangjing Zhang, C. Jane McGlade

The paper analyzes human NUMB alternative splicing across tissues using RNA-seq data to show tissue-specific isoform expression patterns.

DOI 10.1101/2023.09.26.559629

humanbulk RNA-seq

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