Lipid interactions enhance activation and potentiation of cystic fibrosis transmembrane conductance regulator (CFTR)
Stephanie Chin, Mohabir Ramjeesingh, Maurita Hung, June Ereño-Oreba, Christopher E Ing, Zhi W. Zeng, Hong Cui, Jean-Philippe Julien, Régis Pomès, Christine Bear
This study shows that lipid interactions are crucial for CFTR channel activation and potentiation, as demonstrated by higher catalytic activity and response to ivacaftor when CFTR is purified with associated lipids.
bioRxiv · Dec 16, 2018 · PreprintBiophysics