Christine E. Bear

Bioengineered 3D hPSC-cholangiocyte ducts with physiological signals for biliary disease modelling

This paper develops a 3D model of human cholangiocytes to study biliary disease mechanisms by incorporating physiological signals and stromal cells.

A technique for evaluating calcium flux in primary airway tissue at single cell resolution

The paper develops a method to study calcium flux in primary human airway tissue at single-cell resolution using live imaging and machine learning analysis.

Benchmarking organ-specific responses to therapies in tissues differentiated from Cystic Fibrosis patient derived iPSCs

This study benchmarks Trikafta's efficacy in CF patient-derived iPSC-derived colonic and airway tissues compared to isogenic controls, showing differential therapeutic responses.

Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity.

This study creates a single-cell atlas of human fetal lung development, revealing epithelial cell plasticity and lineage hierarchies through scRNA-seq and spatial transcriptomics.

Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells

This study compares a novel CFTR potentiator, SK-POT1, to ivacaftor in improving mucociliary clearance in airway epithelial cells exposed to cigarette smoke.

High-throughput functional analysis of CFTR and other apically localized channels in iPSC derived intestinal organoids

The paper describes a high-throughput fluorescence-based assay to measure CFTR and other apical membrane protein activity in iPSC-derived intestinal organoids.

A new platform for high-throughput therapy testing on iPSC-derived, immature airway from Cystic Fibrosis Patients

This paper describes a fluorescence-based platform for high-throughput Cystic Fibrosis therapy testing using iPSC-derived immature airway epithelium.

Modeling lung cell development using human pluripotent stem cells

This study uses human pluripotent stem cells to model lung development, generating renewable lung epithelial spheroids and identifying new cell lineage relationships.

Lipid interactions enhance activation and potentiation of cystic fibrosis transmembrane conductance regulator (CFTR)

This study shows that lipid interactions are crucial for CFTR channel activation and potentiation, as demonstrated by higher catalytic activity and response to ivacaftor when CFTR is purified with associated lipids.