Author

Mohabir Ramjeesingh

Great Ormond Street Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:cryo-EM· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Christine E. BeariD· 2 shared Adrian Constantin Tanjala· 1 shared Canhui LiiD· 1 shared Christopher E Ing· 1 shared Claire Townsend· 1 shared Daniel V. Paone· 1 shared Gabrielle Langeveld· 1 shared Hong Cui· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPhysiology

Christine E. BearORCID

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2 papers

Recent·Most cited

Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells

Adrian Constantin Tanjala, Jia Xin Jiang, Paul D. W. Eckford, Mohabir Ramjeesingh, Canhui Li, Ling‐Jun Huan, Gabrielle Langeveld, Claire Townsend, Daniel V. Paone, Jakob Busch‐Petersen, Roman Pekhletski, Liping Tang, Vamsee Raju, Steven Mark Rowe, Christine E. Bear

This study compares a novel CFTR potentiator, SK-POT1, to ivacaftor in improving mucociliary clearance in airway epithelial cells exposed to cigarette smoke.

Respiratory Research · Jul 9, 2024Peer-reviewedPhysiology

Lipid interactions enhance activation and potentiation of cystic fibrosis transmembrane conductance regulator (CFTR)

Stephanie Chin, Mohabir Ramjeesingh, Maurita Hung, June Ereño-Oreba, Christopher E Ing, Zhi W. Zeng, Hong Cui, Jean-Philippe Julien, Régis Pomès, Christine Bear

This study shows that lipid interactions are crucial for CFTR channel activation and potentiation, as demonstrated by higher catalytic activity and response to ivacaftor when CFTR is purified with associated lipids.

bioRxiv · Dec 16, 2018 · PreprintBiophysics