Régis Pomès

This study identifies a stable open conformation of human CFTR through simulations, showing it matches experimental Cl- conductance properties and highlights key residues and structural features involved in ion permeation.

This study reveals the structural basis of Plasmodium vivax inhibition by antibodies targeting the CSP repeats through molecular dynamics simulations and crystal structure analysis of inhibitory monoclonal antibodies.

This study shows that lipid interactions are crucial for CFTR channel activation and potentiation, as demonstrated by higher catalytic activity and response to ivacaftor when CFTR is purified with associated lipids.