Spatially confined niches support hypoxia-associated transcriptional plasticity contributing to malignant progression in IDH-mutant gliomas
Depro Das, Alina Pandele, Vatsal D. Jariwala, Nishitha S Ghariwala, Aso O. Mohammed, Tonmoy Das, Christopher Krolla, Saif Mukramoon Arosh, Naiem Hossain, Mohammad Al Shhab, Md. Ismail Hosen, Stuart J. Smith, Juergen Grauvogel, Ioannis Vasilikos, Roland Roelz, , Sajib Chakraborty
This study identifies hypoxia-associated transcriptional plasticity in IDH-mutant gliomas, showing microglia-driven quiescent-to-activated transitions that drive malignant progression.
bioRxiv · Jun 3, 2026 · PreprintCancer Biology