Itay Tirosh

Spatially confined niches support hypoxia-associated transcriptional plasticity contributing to malignant progression in IDH-mutant gliomas

This study identifies hypoxia-associated transcriptional plasticity in IDH-mutant gliomas, showing microglia-driven quiescent-to-activated transitions that drive malignant progression.

Pan-cancer analysis of single-cell RNA sequencing data from 304 human tumors sheds light on the aneuploidy paradox

This study analyzes single-cell RNA sequencing data from 304 tumors to explore how aneuploidy affects cancer progression and cellular fitness.

Spatial analysis reveals the evolving organization of low-grade and high-grade IDH-mutant glioma

This study uses spatial transcriptomics and proteomics to analyze IDH-mutant gliomas, revealing distinct spatial organization patterns across tumor grades.

Single-cell transcriptomic analysis of HPV-related multiphenotypic sinonasal carcinoma uncovers MYB-HPV association

This study uses scRNA-seq to analyze HPV-related multiphenotypic sinonasal carcinoma and finds an association between HPV and MYB expression, with potential prognostic implications.

Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis

This study shows mutant IDH reprograms neural progenitor cell fate by silencing Gsx2, promoting gliomagenesis through lineage switching.

The Curated Cancer Cell Atlas: comprehensive characterisation of tumours at single-cell resolution

The paper curates a large collection of cancer single-cell RNA-seq datasets, providing a comprehensive resource for analyzing tumor heterogeneity and gene expression patterns across 40 cancer types.

Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single cell RNA sequencing

This study uses single-cell RNA sequencing to identify subtypes and proliferation patterns in small intestine neuroendocrine tumors, revealing non-proliferative neuroendocrine cells and proliferative non-malignant cells.

Glioma synapses recruit mechanisms of adaptive plasticity

This study shows that BDNF-TrkB signaling promotes malignant synaptic plasticity in gliomas, enhancing tumor progression through mechanisms similar to long-term potentiation in the healthy brain.

Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map

The paper evaluates RNAi and CRISPR technologies by analyzing gene expression profiles in the Connectivity Map, finding that RNAi has strong off-target effects while CRISPR is more accurate.

Challenges And Emerging Directions In Single-Cell Analysis

This paper discusses challenges and future directions in single-cell analysis, highlighting advances in technologies and computational methods for studying cellular heterogeneity.