A modification-specific peptide-based immunization approach using CRM197 carrier protein: Development of a selective vaccine against pyroglutamate Aβ peptides
Valérie Vingtdeux, Haitian Zhao, Pallavi Chandakkar, Christopher M. Acker, Peter Davies, Philippe Marambaud
This paper develops a vaccine targeting pyroglutamate Aβ peptides using CRM197 carrier protein, showing it selectively induces antibodies against AβpE3 without cross-reactivity to other Aβ forms.
Molecular Medicine · Jan 1, 2016Peer-reviewedNeuroscience