Peter Davies

Greater Effect of Polygenic Risk Score for Alzheimer's Disease Among Younger Cases Who are Apolipoprotein E-ϵ4 Carriers

The paper examines how polygenic risk scores for Alzheimer's disease affect younger APOE4 carriers, finding earlier disease onset associated with higher PRS.

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

This paper introduces SuStaIn, a machine learning method that identifies disease subtypes and their temporal progression from cross-sectional data, improving prediction of diagnostic conversion in neurodegenerative diseases.

Heritability of regional brain volumes in large-scale neuroimaging and genetic studies

The paper examines the heritability of regional brain volumes using genetic and neuroimaging data from multiple cohorts, finding high heritability and consistent patterns across populations.

A modification-specific peptide-based immunization approach using CRM197 carrier protein: Development of a selective vaccine against pyroglutamate Aβ peptides

This paper develops a vaccine targeting pyroglutamate Aβ peptides using CRM197 carrier protein, showing it selectively induces antibodies against AβpE3 without cross-reactivity to other Aβ forms.