Valérie Vingtdeux

This study shows that p97/VCP regulates APP metabolism by controlling its trafficking and autophagy-dependent degradation of APP-CTFs, linking it to Alzheimer's disease pathology.

This study investigates the roles of endosomal-lysosomal and proteasomal pathways in processing APP-derived fragments, showing distinct degradation mechanisms for full-length APP and overexpressed C99.

This study shows that AMPK is essential for maintaining energy levels during synaptic activation by regulating mitochondrial respiration and supporting synaptic plasticity and memory formation.

This paper develops a vaccine targeting pyroglutamate Aβ peptides using CRM197 carrier protein, showing it selectively induces antibodies against AβpE3 without cross-reactivity to other Aβ forms.