Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation
Geneva N. Kwaku, Kirstine Nolling Jensen, Patricia Simaku, Daniel J. Floyd, Joseph W. Saelens, Christopher M. Reardon, Rebecca Ward, Kyle J. Basham, Olivia W. Hepworth, Tammy D. Vyas, Daniel Zamith‐Miranda, Joshua Daniel Nosanchuk, Jatin M. Vyas, Hannah E. Brown
This study shows that fungal extracellular vesicles induce species-specific immunomodulation in macrophages through endocytosis-dependent mechanisms, with varying cytokine responses and immune signaling.
PLoS Pathogens · May 30, 2025Peer-reviewedMicrobiology