Jatin M. Vyas

An innate immune circuit involving the lectin pathway, complement and lung epithelial cells enforce barrier immunity to inhaled fungal disease

Single-cell analysis of human airway epithelium identifies cell type-specific responses to Aspergillus and Coccidioides

This study uses single-cell RNA sequencing to analyze human airway epithelial cell responses to Aspergillus and Coccidioides, revealing distinct stress and cytokine pathways.

Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation

This study shows that fungal extracellular vesicles induce species-specific immunomodulation in macrophages through endocytosis-dependent mechanisms, with varying cytokine responses and immune signaling.

Macrophage ferroptosis inhibits Aspergillus conidial killing in lung transplantation

This study shows that macrophage ferroptosis impairs Aspergillus killing in lung transplant recipients, increasing fungal infection risk.

Modeling suggests SARS-CoV-2 rebound after nirmatrelvir-ritonavir treatment is driven by target cell preservation coupled with incomplete viral clearance

The paper models viral rebound after nirmatrelvir-ritonavir treatment, finding that target cell preservation and incomplete viral clearance drive rebound, with extended treatment reducing this risk.

Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremia

This study identifies HXA3 as a driver of neutrophil transmigration and elastase release during pneumococcal infection, showing that blocking these processes reduces epithelial damage and bacteremia.