Glucose Metabolism Sustains Aberrant STAT3 Signaling in Colorectal Cancer via Glycosylated Paracrine Factors.
Kathryn Buscher, Kelsey Temprine, Christopher Mays, Noora Aabed, Samuel A. Kerk, Hannah Noelle Bell, Joseph A. Nieto Carrion, Harrison S. Greenbaum, Varun Ponnusamy, Sadeesh Kumar Ramakrishnan, Costas Andreas Lyssiotis, Xiang Xue, Yatrik Madhukar Shah
This study shows glucose metabolism sustains STAT3 activation in colorectal cancer through glycosylated paracrine factors, identifying a potential therapeutic target.
bioRxiv · Jul 22, 2025 · PreprintCancer Biology