Author

Varun Ponnusamy

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Kathryn Buscher· 2 shared Peggy P. HsuiD· 2 shared Yatrik Madhukar ShahiD· 2 shared Adam R. RensloiD· 1 shared Angeline WuiD· 1 shared Ansley S. ConcholaiD· 1 shared Christopher Mays· 1 shared Costas Andreas LyssiotisiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Kathryn Buscher

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Glucose Metabolism Sustains Aberrant STAT3 Signaling in Colorectal Cancer via Glycosylated Paracrine Factors.

Kathryn Buscher, Kelsey Temprine, Christopher Mays, Noora Aabed, Samuel A. Kerk, Hannah Noelle Bell, Joseph A. Nieto Carrion, Harrison S. Greenbaum, Varun Ponnusamy, Sadeesh Kumar Ramakrishnan, Costas Andreas Lyssiotis, Xiang Xue, Yatrik Madhukar Shah

This study shows glucose metabolism sustains STAT3 activation in colorectal cancer through glycosylated paracrine factors, identifying a potential therapeutic target.

bioRxiv · Jul 22, 2025 · PreprintCancer Biology

Labile iron pool dynamics do not drive ferroptosis potentiation in colorectal cancer cells

Varun Ponnusamy, Deahzana R. Randall, Zhenghong Lee, Nupur Kanti Das, Liang Zhao, Kathryn Buscher, Sumeet A. Solanki, Adam R. Renslo, Peggy P. Hsu, Yatrik Madhukar Shah

This study investigates the role of labile iron pool dynamics in ferroptosis in colorectal cancer cells and finds that exogenous iron supplementation reduces cell viability without measurable LIP expansion during ferroptosis.

bioRxiv · Jul 1, 2025 · PreprintCancer Biology

A spatially-resolved blueprint of the developing human lung reveals a basal cell population regulated by a WNT-driven niche

Peggy P. Hsu, Ansley S. Conchola, Tristan Frum, Xiangning Dong, Lila R. Tudrick, Varun Ponnusamy, Michael S. Downey, Manqi Wu, Mengkun Yang, Yusoo Lee, Emma Niestroy, Yu-Hwai Tsai, Angeline Wu, Ian A. Glass, Sofia Diana Merajver, Jason R. Spence

The paper creates a spatially-resolved atlas of the developing human lung, identifying a WNT-driven niche that regulates basal cells.

bioRxiv · Oct 1, 2024 · PreprintDevelopmental Biology