Author

Christopher O’Brien

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Andrei GogaiD· 1 shared Hope S. RugoiD· 1 shared Juha T. KlefströmiD· 1 shared July AungiD· 1 shared Mauricio Jacobo Jacobo· 1 shared Sourav BandyopadhyayiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperCancer Biology

Andrei GogaORCID

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1 paper

Recent·Most cited

MYC Overexpression Confers Sensitivity to TACC3 Inhibition for Triple-Negative Breast Cancer

Mauricio Jacobo Jacobo, July Aung, Christopher O’Brien, Hope S. Rugo, Juha T. Klefström, Sourav Bandyopadhyay, Andrei Goga

This study identifies TACC3 as a vulnerability in MYC-overexpressing triple-negative breast cancers, showing that its inhibition induces cytotoxicity and inflammatory responses.

bioRxiv · Apr 29, 2026 · PreprintCancer Biology