Inhibiting Spinal Cord-Specific Hsp90 Isoforms Reveals a Novel Strategy to Improve the Therapeutic Index of Opioid Treatment
David I. Duron, Parthasaradhireddy Tanguturi, Christopher S. Campbell, Kerry Chou, Paul Bejarano, Katherin A. Gabriel, Jessica L. Bowden, Sanket J. Mishra, Christopher M. Brackett, Deborah J. Barlow, Karen L. Houseknecht, Brian S. J. Blagg, John M. Streicher
This paper shows that inhibiting specific spinal cord Hsp90 isoforms enhances opioid pain relief while reducing tolerance and side effects.
Scientific Reports · Jun 26, 2024Peer-reviewedNeuroscience