NNMT promotes tubular senescence and fibrosis in chronic kidney disease
Lucie Chanvillard, Hildo C. Lantermans, Christopher Wall, Jonathan Thévenet, Loes M. Butter, Loic Tauzin, Nike Claessen, Stefan Christen, Sonia Karaz, Steve Lassueur, Giulia Lizzo, José Luis Sanchez-Garcia, Sylviane Métairon, James A. Holzwarth, Valentina Ferro, , Alessandra Tammaro
This study identifies NNMT as a driver of tubular senescence and fibrosis in CKD, showing its association with senescence markers and protective effects when inhibited.
bioRxiv · Jan 6, 2025 · PreprintCell Biology