Nike Claessen

Chronic exposure to low-concentration urban PM2.5 accelerates maladaptive repair after ischemic injury via mitochondrial dysfunction and lysosomal stress.

This study shows that chronic low-concentration PM2.5 exposure after ischemic injury accelerates CKD through mitochondrial dysfunction and lysosomal stress, with nicotinamide reversing some effects.

Highly Repeatable Tissue Proteomics for Kidney Transplant Pathology: Technical and Biological Validation of Protein Analysis using LC-MS/MS

This paper validates a mass spectrometry-based proteomics workflow for kidney transplant biopsies, showing high repeatability and clinical relevance of protein analysis.

Levamisole-Mediated Suppression of B-Cell Proliferation and Antibody Production Reveals Mechanistic Insights into Idiopathic Nephrotic Syndrome Therapy

This study shows that levamisole suppresses B-cell proliferation and antibody production, offering mechanistic insights into its therapeutic use in idiopathic nephrotic syndrome.

NNMT promotes tubular senescence and fibrosis in chronic kidney disease

This study identifies NNMT as a driver of tubular senescence and fibrosis in CKD, showing its association with senescence markers and protective effects when inhibited.