Structural Basis of Ligand-Specific Orthosteric-Allosteric Coupling and Sensory Tuning in the Human Bitter Taste Receptor TAS2R14
Tao Zhou, Jiening Wang, Chulun Wang, Zhen Han, Yi Zhang, Zishao Ouyang, Sheng Ye, Shan Wu, Anna Qiao
The paper reports cryo-EM structures of TAS2R14-Gi1 complexes bound to different ligands, revealing TM6 dynamics that govern agonist efficacy and allosteric-orthosteric coupling.
bioRxiv · May 17, 2026 · PreprintMolecular Biology