Molecular BiologybioRxivPreprint
Structural Basis of Ligand-Specific Orthosteric-Allosteric Coupling and Sensory Tuning in the Human Bitter Taste Receptor TAS2R14
Tao Zhou, Jiening Wang, Chulun Wang…·Anna Qiao
The paper reports cryo-EM structures of TAS2R14-Gi1 complexes bound to different ligands, revealing TM6 dynamics that govern agonist efficacy and allosteric-orthosteric coupling.
DOI 10.64898/2026.05.14.725165