Somatic mutation in human cerebellum illustrates neuron type-specific patterns of age-related mutation
Kow Essuman, Yingxi Yang, Eitan Goodman, Christie N Cambridge, Chunhui Cai, Zheming An, Shulin Mao, Monica Devi Manam, Benjamin Finander, Sattar Khoshkhoo, Li Sun, August Yue Huang, Christopher A. Walsh
The paper analyzes somatic mutations in cerebellar granule neurons and finds distinct mutation patterns compared to other neuronal types, suggesting links to cancer origins and neurodegeneration.
bioRxiv · Mar 2, 2026 · PreprintNeuroscience