Cell BiologybioRxivPreprint
Lysosomal Dysfunction-Mediated IgG Accumulation Promotes Endothelial Senescence and Lesion Progression in Cerebral Cavernous Malformations
DOI 10.64898/2026.08.29.747964
Author
Yingxi Yang
Broad InstituteORCID 0000-0001-5153-2769Unclaimed ORCID profile · follow to get notified of new preprints
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Biology Disciplines
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2025-2026 · peak 2/yrCo-Author Collaboration Network
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Curved chords = mutual co-authorship3 papers
Recent·Most cited
- NeurosciencebioRxivPreprint
Somatic mutation in human cerebellum illustrates neuron type-specific patterns of age-related mutation
Kow Essuman, Yingxi Yang, Eitan Goodman…·Christopher A. Walsh
The paper analyzes somatic mutations in cerebellar granule neurons and finds distinct mutation patterns compared to other neuronal types, suggesting links to cancer origins and neurodegeneration.
- GeneticsProceedings of the National Academy of SciencesPeer-reviewed
Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs
Sara Bizzotto, Maya Talukdar, Edward Stronge…·Christopher A. Walsh
This study uses snRNA-seq and a new method called GO-TEN to analyze mosaic genetic variants in focal cortical dysplasia, revealing cell-autonomous and non-cell-autonomous transcriptional changes associated with epilepsy.