A structural model of a Ras-Raf signalosome
Venkatesh P. Mysore, Zhi-Wei Zhou, Chiara Ambrogio, Lianbo Li, Jonas N. Kapp, Chunya Lu, Qi Wang, Maxwell R. Tucker, Jeffrey J. Okoro, Gabriela Nagy‐Davidescu, Xiao‐chen Bai, Andreas Plückthun, Pasi Antero Janne, Kenneth D. Westover, Yibing Shan, David Elliot Shaw
The paper proposes an atomistic structural model of a Ras-Raf signalosome based on molecular dynamics simulations, mutagenesis, electron microscopy, and cell-based experiments.
Nature Structural & Molecular Biology · Oct 1, 2021Peer-reviewedMolecular Biology