Kenneth D. Westover

This study investigates how magnesium regulates KRAS conformational dynamics and nucleotide exchange using HDX-MS and functional assays, revealing Mg2+ as a critical structural stabilizer.

This paper introduces Subtimizer, a computational pipeline for designing potent and selective kinase peptide substrates using AI tools, showing improved activity and selectivity in tested kinases.

The paper proposes an atomistic structural model of a Ras-Raf signalosome based on molecular dynamics simulations, mutagenesis, electron microscopy, and cell-based experiments.