Xiao‐chen Bai

Regulation of STING activation by phosphoinositide and cholesterol

This study identifies phosphoinositides and cholesterol as regulators of STING activation by promoting its oligomerization and translocation.

PtdIns(3,5)P2 Is an Endogenous Ligand of STING in Innate Immune Signaling

This study identifies PtdIns(3,5)P2 as an endogenous ligand of STING that cooperates with cGAMP to activate innate immune signaling.

Structural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramer

The paper determines the cryo-EM structure of the IL-17RA, IL-17RB, and ACT1 complex, revealing how these proteins form a hetero-tetramer to initiate immune signaling.

Tuning Insulin Receptor Signaling Using De Novo Designed Agonists

This paper designs synthetic insulin receptor agonists that modulate receptor conformation and signaling, showing improved potency and activity in disease mutants.

Structural insights into the ubiquitin independent MIDN-proteasome pathway

This study reveals how MIDN enhances proteasome activity through cryo-EM structures showing its binding to proteasomes and substrates in two conformational states.

Structural basis for Retriever-SNX17 assembly and endosomal sorting

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

Cmai: Predicting Antigen-Antibody Interactions from Massive Sequencing Data

Cmai predicts antigen-antibody interactions from high-throughput BCR sequencing data, revealing immune responses to tumor antigens and ICI treatment outcomes.

CTCF and R-loops are boundaries of cohesin-mediated DNA looping

This study shows that CTCF orientation and R-loops regulate cohesin-mediated DNA looping and 3D genome structure.

A structural model of a Ras-Raf signalosome

The paper proposes an atomistic structural model of a Ras-Raf signalosome based on molecular dynamics simulations, mutagenesis, electron microscopy, and cell-based experiments.