Chiara Ambrogio

This paper analyzes age-related changes in bovine thymus using multimodal techniques to identify mechanical, compositional, and spatial alterations that inform the design of regenerative biomaterials.

This study shows that targeted KRAS(G12V) degradation causes durable lung adenocarcinoma regression in mice, with tumor relapse linked to proteolysis machinery dysregulation.

This study shows that the SOS1 inhibitor BI-3406 effectively reduces tumor growth in KRAS mutant cancers, similar to genetic SOS1 ablation, with comparable efficacy to another KRAS inhibitor.

scPharm integrates pharmacogenomics profiles with scRNA-seq data to identify drug-sensitive subpopulations in cancer tissues and predict combination therapies.

The paper proposes an atomistic structural model of a Ras-Raf signalosome based on molecular dynamics simulations, mutagenesis, electron microscopy, and cell-based experiments.