David Elliot Shaw

This study identifies an RNA-mediated DNA melting mechanism in CRISPR-Cas9 using simulations and experiments, showing RNA bases intercalate to promote strand separation.

The paper designs antigens that present a tumor-specific cryptic epitope in the conformation recognized by mAb806, showing successful stabilization of the epitope in vitro.

The paper proposes an atomistic structural model of a Ras-Raf signalosome based on molecular dynamics simulations, mutagenesis, electron microscopy, and cell-based experiments.