Novel mouse models for perianal fistulizing Crohns disease reveal therapeutic value of interferon-gamma antagonists
Xin Yao, Kaiming Ma, David H. Ballard, Echo Zhu, Xiuli Liu, Lingjie Huang, Chuwen Tian, James D. Quirk, Heather S. Ruiz, Tingyi Tan, Matthew A. Ciorba, Gwendalyn J. Randolph, Parakkal Deepak, Siyan Cao
This study develops mouse models of perianal fistulizing Crohn's disease and identifies IFN-gamma signaling as a therapeutic target.
bioRxiv · Jun 8, 2026 · PreprintImmunology