Damage-induced IL-18 stimulates thymic NK Cells limiting endogenous tissue regeneration
David Granadier, Kirsten Cooper, Dante Dennis Acenas II, Anastasia I. Kousa, Makya Warren, Vanessa A Hernandez, Lorenzo Iovino, Paul C. DeRoos, Emma E. Lederer, Steve Shannon-Sevillano, Sinead M. Kinsella, Cindy Evandy, Marcel R.M. van den Brink, Andri Leó Lemarquis, Jarrod A. Dudakov
This study shows that IL-18, generated in the thymus after tissue damage, limits thymic regeneration by targeting TECs, suggesting IL-18 as a therapeutic target and highlighting potential off-target effects in cancer immunotherapy.
Nature Immunology · Sep 11, 2025Peer-reviewedImmunology