Damage-induced IL-18 stimulates thymic NK Cells limiting endogenous tissue regeneration
David Granadier, Kirsten Cooper, Dante Dennis Acenas II…·Jarrod A. Dudakov
This study shows that IL-18, generated in the thymus after tissue damage, limits thymic regeneration by targeting TECs, suggesting IL-18 as a therapeutic target and highlighting potential off-target effects in cancer immunotherapy.