Author

Paul C. DeRoos

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 1

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Anastasia I. KousaiD· 1 shared Andri Leó LemarquisiD· 1 shared Cindy Evandy· 1 shared Dante Dennis Acenas IIiD· 1 shared David GranadieriD· 1 shared Emma E. LedereriD· 1 shared Jarrod A. DudakoviD· 1 shared Kirsten CooperiD· 1 shared

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2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Anastasia I. KousaORCID

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1 paper

Recent·Most cited

Damage-induced IL-18 stimulates thymic NK Cells limiting endogenous tissue regeneration

David Granadier, Kirsten Cooper, Dante Dennis Acenas II, Anastasia I. Kousa, Makya Warren, Vanessa A Hernandez, Lorenzo Iovino, Paul C. DeRoos, Emma E. Lederer, Steve Shannon-Sevillano, Sinead M. Kinsella, Cindy Evandy, Marcel R.M. van den Brink, Andri Leó Lemarquis, Jarrod A. Dudakov

This study shows that IL-18, generated in the thymus after tissue damage, limits thymic regeneration by targeting TECs, suggesting IL-18 as a therapeutic target and highlighting potential off-target effects in cancer immunotherapy.

Nature Immunology · Sep 11, 2025Peer-reviewedImmunology