IL-12 restores the sequential cytotoxic capacities of anti-GD2 CAR-T and CAR-iNKT cells against glioblastoma
Dai Tran, Cindy Lamorlette, Loris Gerard, Jordan Brouard, Gianpietro Dotti, David Moulin, Loïc Reppel, Cécile Pochon, Marie‐Thérèse Rubio
This study shows that IL-12 enhances the anti-glioblastoma efficacy of GD2-targeted CAR-T and CAR-iNKT cells by improving their persistence and function after repeated antigen exposure.
bioRxiv · Aug 25, 2026 · PreprintImmunology