Orally Delivered Milk-Derived Nanovesicles Loaded with Connexin 43 Peptides forTargeted Cardiac Ischemia-Reperfusion Therapy
Spencer R. Marsh, Md Ruhul Amin, Stefano A Toldo, Claire E. Beard, Alan B. Dogan, Eleonora Mezzaroma, Ethan Andres, Randy F. Stout, Mark S. Bannon, Laura Beth Payne, Antonio Abbate, Yassine Sassi, Rachel A. Letteri, Robert G. Gourdie
This paper develops orally deliverable milk-derived nanovesicles loaded with Cx43 peptides to treat cardiac ischemia-reperfusion injury, showing >60% reduction in infarct size in mice.
bioRxiv · Jan 1, 2025 · PreprintBioengineering