Molecular BiologybioRxivPreprint
Limited specificity of molecular interactions incurs an environment-dependent fitness cost in bacteria
Claudia Igler, Claire Fourcade, Torsten Waldminghaus…·Călin C. Guet
The paper shows that non-specific TF-DNA binding in bacteria reduces population growth across environments due to low specificity, TF cooperativity, and TF-to-DNA ratios.
2 citations