Călin C. Guet

The paper shows that CRISPR-mediated herd immunity in E. coli promotes frequent homologous recombination by maintaining genetic diversity and enabling gene flow, enhancing adaptation rates.

This study shows that ATP and PMF coupling in E. coli depends on growth conditions, with PMF being essential for growth regardless of ATP synthesis function.

The paper shows that basal gene expression in bacteria is not inert but consists of stochastic pulses that enhance fitness by accelerating growth and reducing lag times during environmental transitions.

The paper develops a mechanistic model of bacterial promoters to explore how molecular complexity affects evolutionary predictions, finding that simplifying mechanisms does not compromise accuracy.

The paper studies the conservation and evolution of intrinsic transcriptional terminators between Escherichia coli and Salmonella enterica subsp. pullorum, finding low sequence and functional conservation despite their close relation.

The paper studies the mar operon in E. coli using single-cell lineage tracking, revealing inducible memory of promoter activity across generations.

The paper shows that non-specific TF-DNA binding in bacteria reduces population growth across environments due to low specificity, TF cooperativity, and TF-to-DNA ratios.

The paper shows that a fixed gene regulatory network can display different phenotypes based on local genetic context, highlighting the role of transcriptional unit order.