Florian M. Pauler

The paper identifies a human-specific transcriptomic deletion in HMMR that affects cell division plasticity and links cortical expansion to cancer risk.

This study investigates the role of Pten in radial glial progenitor lineage progression and astrocyte production during cortical development, finding that Pten loss increases astrocyte generation and disrupts growth factor signaling.

This study investigates the role of Mtor/Rptor in cortical development, finding that its loss causes microcephaly through tissue-wide effects, while cell-autonomous Rptor function is critical for postnatal neuron survival in a cell-type-specific manner.

This study identifies multipotent progenitors in the superior colliculus that generate all excitatory and inhibitory neuron types without extrinsic input.

The paper investigates how changes in large neutral amino acid metabolism during development affect neuronal excitability and survival, finding that Slc7a5 deletion disrupts lipid metabolism and leads to long-term circuit dysfunction.

The paper shows PRC2 has distinct, sequential functions in RGP lineage progression, acting tissue-wide for proliferation and cell-autonomously for astrocyte maturation.

This study shows that tissue-wide genetic effects override cell-intrinsic gene function in cortical neuron migration using MADM and single-cell analysis.

The paper shows that non-specific TF-DNA binding in bacteria reduces population growth across environments due to low specificity, TF cooperativity, and TF-to-DNA ratios.

The paper uses scRNA-seq data from mouse brain cortex to identify cell types and lineages by analyzing LOH events and gene expression patterns.

The paper identifies novel imprinted genes in mouse blastocysts and shows that their expression is mostly independent of DNA methylation but associated with H3K27me3 marks.