Pre-myelinating oligodendrocyte ADGRG1 is required for axon ensheathment and CNS myelin formation
Beika Zhu, Tao Li, Benjamin V Rodrigues, Melanie Piller, Cody L. Call, Amit Mogha, Arantzazu Belloso-Iguerategui, Brian Chiou, Rachael Schmidt, Andi Wangzhou, Alicia L Thurber, Madison Dee, Claire Larson, Kelly R. Monk, Xianhua Piao
This study identifies ADGRG1 as a key regulator of pre-myelinating oligodendrocyte development and axon ensheathment, showing its role in CNS myelin formation through RhoA activation.
bioRxiv · Jan 27, 2026 · PreprintNeuroscience