Andi Wangzhou

The paper identifies microglia-like cells in human dorsal root ganglia and shows their changes in diabetic neuropathy.

This study identifies ADGRG1 as a key regulator of pre-myelinating oligodendrocyte development and axon ensheathment, showing its role in CNS myelin formation through RhoA activation.

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

The paper investigates neuronal gene expression changes in skin biopsies from paclitaxel-induced peripheral neuropathy patients using bulk RNA sequencing and spatial transcriptomics.

The paper shows microglia regulate GABAergic neurogenesis in the prenatal human brain via IGF1, using single-cell transcriptomics and organoid models.

This study uses snRNA-seq to identify molecular features of human airway microfold cells and discovers a novel epithelial cell type with an interferon-stimulated gene signature.

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

This study shows that ADGRG1 in microglia helps protect against Alzheimer's disease by improving amyloid clearance and reducing pathology.

The paper identifies Nageotte nodules in diabetic painful neuropathy DRGs, showing they contain dead neurons and are linked to pain and sensory loss.

This study shows that sustained depolarization reduces excitability in mouse and human sensory neurons through decreased voltage-gated sodium currents, suggesting homeostatic plasticity may be altered in chronic pain.

The paper compares receptor expression diversity between central and peripheral mouse neurons using single-cell RNA sequencing and finds similar diversity overall, with exceptions in GPCRs and cytokine receptors.

The paper uses spatial transcriptomics to characterize human sensory neurons, comparing them to mouse and non-human primate data to identify similarities and divergences in drug targets.

The paper identifies sex differences in nociceptor translatomes, revealing sex-specific prostaglandin signaling differences in male and female mice.

The paper shows that human dorsal root ganglion neurons express ACE2, suggesting they may be a target for SARS-CoV-2 entry into the nervous system.

This study identifies a specific subset of sensory neurons expressing PAR2 that mediate mechanical and affective pain behaviors, clarifying the cellular basis of PAR2-evoked pain.

The paper creates interactome maps of ligand-receptor interactions between peripheral cell types and sensory neurons in mouse and human disease states, identifying potential therapeutic targets like EGFR.

This study shows type I interferons act directly on nociceptors via MNK-eIF4E signaling to cause pain hypersensitivity in mice, linking viral infections to pain and neuropathies.

The paper compares transcriptomes of native and cultured human and mouse dorsal root ganglia, finding reduced neuronal gene expression in culture but presence of key pharmacological targets.

The paper analyzes human tibial nerve transcriptomes to identify sex-dimorphic gene expression related to pain, inflammation, and neuro-immunity.

The paper identifies the RagA-mTORC1 network as a key driver of neuropathic pain through cell-specific translational profiling in nociceptors.

The paper compares human and mouse dorsal root ganglia transcriptomes using RNA-seq, identifying enriched genes and pathways relevant to pain and sensory neuroscience.