Xianhua Piao

The paper provides a high-resolution molecular and cellular analysis of Broca's area and motor cortex across developmental stages, identifying distinct cellular signatures and vulnerabilities to neurodevelopmental disorders.

This study identifies ADGRG1 as a key regulator of pre-myelinating oligodendrocyte development and axon ensheathment, showing its role in CNS myelin formation through RhoA activation.

The paper shows microglia regulate GABAergic neurogenesis in the prenatal human brain via IGF1, using single-cell transcriptomics and organoid models.

This study shows that ADGRG1 in microglia helps protect against Alzheimer's disease by improving amyloid clearance and reducing pathology.

This study creates a cross-species proteomic map of synapse development in human, macaque, and mouse neocortex, revealing slower human PSD maturation and its potential link to neoteny.

This study shows that Gpr56 and Gpr97 have redundant roles in mammalian hematopoietic cell development and differentiation, with Gpr97 compensating for Gpr56 loss in zebrafish and mouse models.

This study identifies a specific GPR56 splicing isoform that mediates microglial synaptic pruning through phosphatidylserine binding, linking it to neurodevelopmental processes.

This study maps human microglia development and identifies cytokine-associated subtypes and functional roles in neural network maturation.

This study identifies nine distinct microglial states in mice across lifespan and after injury using single-cell RNA sequencing, revealing persistent and age-related changes.