The p.H222P lamin A/C mutation induces heart failure via impaired mitochondrial calcium uptake in human cardiac laminopathy
Magali Seguret, Charlène Jouve, Andrea Ruiz‐Velasco, Lucille Deshayes, Zoheir Guesmia, Céline Pereira, Valentine Ragot, Clara Castelli, Karim Wahbi, Jérémy Fauconnier, Gisèle Bonne, Antoine Muchir, Jean‐Sébastien Hulot
This study investigates how the LMNA p.H222P mutation causes heart failure by impairing mitochondrial calcium uptake in human cardiac cells.
Cardiovascular Research · Jul 21, 2026Peer-reviewedPathology