Author

Antoine Muchir

InsermORCID 0000-0002-4780-9275Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Zoheir GuesmiaiD· 2 shared Albano C. MéliiD· 1 shared Andrea Ruiz‐VelascoiD· 1 shared Anne ForandiD· 1 shared Azzouz Charrabi· 1 shared Cécile PeccateiD· 1 shared Céline Pereira· 1 shared Charlène JouveiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPathology

Zoheir GuesmiaORCID

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2 papers

Recent·Most cited

The p.H222P lamin A/C mutation induces heart failure via impaired mitochondrial calcium uptake in human cardiac laminopathy

Magali Seguret, Charlène Jouve, Andrea Ruiz‐Velasco, Lucille Deshayes, Zoheir Guesmia, Céline Pereira, Valentine Ragot, Clara Castelli, Karim Wahbi, Jérémy Fauconnier, Gisèle Bonne, Antoine Muchir, Jean‐Sébastien Hulot

This study investigates how the LMNA p.H222P mutation causes heart failure by impairing mitochondrial calcium uptake in human cardiac cells.

Cardiovascular Research · Jul 21, 2026Peer-reviewedPathology

The Mutated p.H222P A-type Lamins Drive Loxl2-Mediated Extracellular Matrix Remodeling in Both Patient-Derived Cardiomyocytes and Mouse Models of Dilated Cardiomyopathy

Marie Kervella, Cécile Peccate, Zoheir Guesmia, Fiorella Carla Grandi, Nathalie Mougenot, Anne Forand, Azzouz Charrabi, Guy Brochier, Ramaroson Andriantsitohaina, Albano C. Méli, Antoine Muchir

This study identifies Loxl2 as a therapeutic target for LMNA cardiomyopathy by showing its role in ECM remodeling in patient-derived cardiomyocytes and mouse models.

bioRxiv · Jan 10, 2025 · PreprintPathology