Jean‐Sébastien Hulot

This study investigates the pathogenic effects of the DES p.R406W mutation, showing it causes electrical and structural heart remodeling linked to arrhythmias and sudden cardiac death.

This study investigates how the LMNA p.H222P mutation causes heart failure by impairing mitochondrial calcium uptake in human cardiac cells.

This study evaluates mavacamten's effects on energy balance in RASopathy-associated HCM using hiPSC-CMs with a BRAF mutation.

This study shows that structured alignment of cardiomyocytes improves mitochondrial function and bioenergetic efficiency, highlighting the role of cellular organization in heart health.

This study establishes an adrenocortical cell model to modulate sodium entry and calcium signaling, revealing its role in aldosterone biosynthesis and PA development.