Author

Magali Seguret

InsermORCID 0000-0002-3059-3113Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Andrea Ruiz‐VelascoiD· 2 shared Céline Pereira· 2 shared Charlène JouveiD· 2 shared Jean‐Sébastien HulotiD· 2 shared Antoine MuchiriD· 1 shared Clara Castelli· 1 shared Elodie Vimont· 1 shared Erminia DonnarummaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersPathology

Andrea Ruiz‐VelascoORCID

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2 papers

Recent·Most cited

PathologyCardiovascular ResearchPeer-reviewedJul 21, 2026

The p.H222P lamin A/C mutation induces heart failure via impaired mitochondrial calcium uptake in human cardiac laminopathy

Magali Seguret, Charlène Jouve, Andrea Ruiz‐Velasco…·Jean‐Sébastien Hulot

This study investigates how the LMNA p.H222P mutation causes heart failure by impairing mitochondrial calcium uptake in human cardiac cells.

6 citationstop 5%

humanbulk RNA-seq

Cell BiologyCommunications BiologyPeer-reviewedOct 9, 2025

Myocardial disarray drives metabolic inefficiency in human cardiomyocytes

Charlène Jouve, Andrea Ruiz‐Velasco, Erminia Donnarumma…·Jean‐Sébastien Hulot

This study shows that structured alignment of cardiomyocytes improves mitochondrial function and bioenergetic efficiency, highlighting the role of cellular organization in heart health.

3 citations

humanbulk RNA-seq