Clare Fitzpatrick

The AGEF-1/ARF-1 GTPase/AP-1 trafficking pathway differentially regulates LIN-12/Notch signaling in a tissue specific manner in C. elegans

This paper shows that the AGEF-1/ARF-1/AP-1 trafficking pathway promotes LIN-12/Notch signaling in the somatic gonad and inhibits it in vulval precursor cells, regulating vulval development in C. elegans.

An activating mutation in AGEF-1, a putative Arf GEF, causes yolk extrusion from C. elegans embryos

The paper identifies an activating mutation in C. elegans AGEF-1 that causes yolk extrusion, suggesting a role for Arf GTPase cycling in membrane trafficking.