Olga Skorobogata

This paper shows that the AGEF-1/ARF-1/AP-1 trafficking pathway promotes LIN-12/Notch signaling in the somatic gonad and inhibits it in vulval precursor cells, regulating vulval development in C. elegans.

The paper identifies an activating mutation in C. elegans AGEF-1 that causes yolk extrusion, suggesting a role for Arf GTPase cycling in membrane trafficking.

This study shows that phosphorylation of Rab7A at serine 72 modulates its palmitoylation and retromer recruitment, with NEK7 as the kinase responsible for this phosphorylation.

This study shows that centralspindlin is essential for cytokinesis during early embryonic divisions but has incomplete requirements in postembryonic development, affecting anchor cell specification and vulva morphogenesis.