Christian E. Rocheleau

This study shows TBC-2 regulates the localization of PQM-1 and HLH-30/TFEB transcription factors in C. elegans intestine, impacting IIS pathway function.

This paper shows that the AGEF-1/ARF-1/AP-1 trafficking pathway promotes LIN-12/Notch signaling in the somatic gonad and inhibits it in vulval precursor cells, regulating vulval development in C. elegans.

The paper identifies an activating mutation in C. elegans AGEF-1 that causes yolk extrusion, suggesting a role for Arf GTPase cycling in membrane trafficking.

This study shows that ALG-1, a microRNA argonaute, promotes vulva induction in C. elegans independently of the LET-60 Ras pathway.

This study shows that centralspindlin is essential for cytokinesis during early embryonic divisions but has incomplete requirements in postembryonic development, affecting anchor cell specification and vulva morphogenesis.